Ugg! Well, it all worked -until I shut down. - Same problem again today (buttons didn't work in 3d-coat) until I re-installed the driver again. I've emailed 3dconnexion about it, so I'll see what they say, but I'm guessing it's my machine. Funny though, no problems like that in blender at all. The buttons continue to work, whereas they don't in 3d coat till driver re installation.
On the bright side, I'm getting really good at re-installing drivers! lol