You can sculpt with a mouse but not only will it destroy your wrist but you'll be playing with size settings and things that can be controller with the pressure input. You'll waste a lot of time in doing so as well.
Honestly, it took me a bit of getting used to my XP-PEN ( https://www.xp-pen.com ) drawing tablet at first, but as soon as I did, it was absolutely worth it. I don't use it as a mouse like some of my peers do (I use 3 monitors, so it just doesn't work effectively - I restrain it to my primary screen when I'm working with it), but it's definitely a must have for sculpting in 3D Coat or Zbrush . After adjusting to how it translates to screen space, it became much more natural.
